摘要
目的:探讨长时和短时收缩压变异性指标与老年人群肾脏损害的关联。方法:在参加开滦研究队列第三次健康体检的人群中,采取整群抽样的方法按照25%比例随机抽取年龄≥60岁的开滦集团离退休员工进行24小时动态血压监测等检查。在随机抽取的3 064例观察对象中,符合入选标准的为2 464例。收缩压变异性(SBPV)采用标准差(SSD)、独立变异性(VIM)、极差(MMD)和平均真实变异性(ARV)四种指标;肾脏损害采用肾小球滤过率(eGFR)、尿微量白蛋白(ALBU)两种指标。采用逐步线性回归方法,分析不同长时和短时SBPV指标与eGFR、ALBU的关联。结果:(1)在2 464例观察对象中,年龄平均为(67.41±6.05)岁。其中,男性1 667例(67.7%),女性797例(32.3%)。(2)在逐步线性回归分析中,不同长时SBPV指标均与eGFR、ALBU无线性相关;四项24h SBPV指标、三项日间SBPV指标(SSD、MMD、ARV)均与eGFR呈负线性相关,24 h ARV、日间MMD、日间ARV均与ALBU呈正线性相关,夜间SBPV指标均与eGFR、ALBU无线性相关。结论:不同短时收缩压变异性指标与eGFR、ALBU均存在一定程度的关联。
Objective: To investigate the relationship between long-, short-term systolic blood pressure variability(SBPV) and renal damage in elder population.Methods: Our research was conducted in the 3^rd physical examination of healthy population from Kailuan group by cohort study. Cluster sampling was used by 25% ratio in subjects≥60 years of age to monitor their 24-hour ambulatory blood pressure and finally, 2464/3064 participants with inclusion criteria were recruited. SBPV indexes as standard deviation of systolic blood pressure(SSD), variability independent of the mean(VIM), maximum-minimum difference(MMD) and average real variability(ARV) were examined; renal damage indexes as estimated glomerular filtration rate(eGFR) and microalbuminuria(ALBU) were detected. Relationships between different long-term, short-term SBPV indexes and eGFR, ALBU were studied by multi-liner regression analysis.Results:(1) The mean age of 2464 participants was(67.41 ± 6.05) years including 1667(67.7%) male and 797(32.3%) female.(2) Multi-liner regression analysis indicated that different long-term SBPV indexes were not related to eGFR and ALBU; 24 h SBPV in all 4 indexes and day-time SSD, MMD, ARV were negatively related to eGFR; 24 h ARV and day-time MMD, ARV were positively related to ALBU; night-time SBPV indexes were not related to eGFR and ALBU.Conclusion: Different short-term SBPV indexes were, at certain point related to eGFR and ALBU.
出处
《中国循环杂志》
CSCD
北大核心
2016年第5期467-471,共5页
Chinese Circulation Journal
关键词
收缩压变异性
老年人群
肾小球滤过率
尿微量白蛋白
Systolic blood pressure variability
Elder population
Glomerular filtration rate
Microalbuminuria