解毒凉血健脾法治疗乙型肝炎慢加急性肝功能衰竭理论探析

Analysis of the method of detoxification and cooling blood and invigorating spleen to treat HBV-related acute-on-chronic liver failure

慢加急性肝衰竭是在慢性肝病基础上出现的急性肝功能失代偿,乙型肝炎病毒感染是其主要病因。该病病机复杂,病情进展迅速,病死率高,基于本病"湿、热、毒、瘀、虚"相互胶结的核心病机,笔者综合运用"清热解毒、凉血活血、健脾化湿"治疗该病取得了较好疗效,文章就这一治则治法及遣方用药进行了理论探析。

Acute-on-chronic liver failure is a severe life-threatening clinical syndrome characterized by acute deterioration in liver function caused by precipitating events such as hepatitis B virus(HBV).It was characterized by complicated etiology and pathogenesis, rapid progress and high fatality rate.Based on its core pathogenesis including the intermingling of dampness, heat, toxin, stasis and deficiency, we applied the treatment principles including clearing heat and removing toxicity, cooling and activating blood and invigorating spleen for eliminating dampness into treating the HBV-related acute-on-chronic liver failure that achieve a better therapeutic effect.The theory basis of the therapeutic principle and method is explored in this paper.