基于非条件Logistic回归分析的支气管哮喘慢性持续期证候特征研究

Syndrome characteristics of bronchial asthma in chronic duration:An unconditioned Logistic regression analysis

目的:研究支气管哮喘慢性持续期的证候特征。方法:采用SPSS 20.0软件,对697例通过多中心、前瞻性、开放式、有监督无监督相结合的观察性研究方法采集的支气管哮喘慢性持续期患者的证候与症状、体征、舌苔脉象进行非条件Logistic回归分析。结果:通过对证候、症状、体征、舌苔脉象进行非条件Logistic回归分析,显示证候与症状之间存在相关性。肺脾两虚证与纳呆、乏力、易外感、大便溏等症状相关;肺肾亏虚证与眩晕、腰膝酸软、易外感相关;痰热蕴肺与口渴、痰黏难咳、黄苔等症状具有相关性;痰湿壅肺与咯痰、胸膈满闷、腻苔、滑脉、纳呆存在潜在联系。结论:支气管哮喘慢性持续期涉及多脏腑的功能失调,尤以肺脾为核心,痰饮、瘀血等病理产物共存,呈现本虚标实、寒热错杂的证候特征。

Objective:To investigate the syndrome characteristics of bronchial asthma in chronic duration.Methods:An observation of study with multicenter, prospective, open, combinated supervised with unsupervised was launched to collect information from the total of 697 cases of patients with bronchial asthma in chronic duration including syndrome, symptoms, signs, tongue coating and pulse.Then the unconditioned Logistic regression analysis was used to conduct these data according to SPSS 20.0 software.Results:The results of Logistic regression analysis showed that there was a close correlation between the syndrome and symptoms.The syndrome of deficiency of both lung and spleen correlated with the symptoms including anorexia, weakness, panting, susceptible to common cold, and loose stool.The syndrome of deficiency of both kidney and lung correlated with the symptoms including vertigo, tinnitus, soreness and weakness of waist and knees, and susceptible to common cold.The syndrome of phlegm-heat obstructing lung correlated with the symptoms including thirst, adhesive phlegm and yellow fur.The syndrome of phlegm-dampness obstructing lung potentially correlated with the symptoms including expectoration, chest and diaphragm distress, greasy fur, slippery pulse and anorexia.Conclusion:The bronchial asthma in chronic duration involves dysfunction of many zang-fu viscera, especially the lung and spleen as the core.The pathological products including phlegm and blood stasis coexist when the bronchial asthma being in chronic duration.In addition, it shows the syndrome characteristics with deficient root cause and excessive manifestation as well as intermingled cold and heat.