加减阳和汤在内毒素性肺损伤伴发真菌感染治疗中的作用

Effects of modified Yanghe Decoction in treating endotoxin-induced lung injury with fungal infection

目的:观察加减阳和汤在肺损伤伴发真菌感染临床治疗中的协同作用。方法:将32例肺损伤伴发真菌感染的患者随机分为两组,对照组15例给予抗真菌等常规综合治疗,治疗组17例辅以加减阳和汤治疗。在服药后比较两组患者服药后7、14d外周血中性粒细胞计数及血、肺泡灌洗液G试验结果等变化。结果:治疗组14d外周血中性粒细胞水平较对照组明显改善(P<0.05)。治疗组患者外周血及肺泡灌洗液的G试验结果转阴例数优于对照组(P<0.05,P<0.01)。结论:临床上运用加减阳和汤治疗肺损伤真菌感染能协同抗真菌药提高疗效。

Objective:To study the synergistic effect of Yanghe Decoction in treating endotoxin-induced lung injury with fungal infection.Methods:Thirty-two patients with endotoxin-induced lung injury with fungal infection were randomly divided into 2 groups, patients in control group were treated with anti-fungal and other conventional comprehensive treatment, and patients in treatment group were treated with Yanghe Decoction based on the anti-fungal and other conventional comprehensive treatment.The changes of neutrophil count and blood and bronchoalveolar lavage fluid G were compared between the two groups after treatment.Results:In the treatment group, the neutrophil level in the peripheral blood was significantly improved at each observation time point compared with the control group(P<0.05).Compared with the control group, there were significant differences in the number of G-test results of peripheral blood and alveolar lavage fluid in the treatment group(P<0.05), and the results of bronchoalveolar lavage fluid were significantly different(P<0.01).Conclusion:Application of modified Yanghe and decoction combined with anti-fungal drugs in treating lung injury with fungal infection could improve the curative effect.