非可控性炎症对Hp相关胃病恶性演变与中医证候研究的启示

Investigative hypothesis regarding the malignant evolution of kelicobacter pylori-related gastric disease and Chinese medicine syndromes via non-resolving inflammation

非可控性炎症(NRI)是宿主、机体微环境与病原微生物相互作用的复杂病理过程,作为炎症的中心环节,NF-κB信号通路和microRNA分子异常所致的炎症因子、趋化因子异常表达,以及炎性细胞功能的失调,可能是幽门螺杆菌相关胃病(HPGD)NRI发生的分子基础;文章初步提出"邪毒致变"的观点,并据此探讨HPGD恶性演变过程中,炎性微环境改变与不同中医证候特征关联的可能性。

Non-resolving inflammation(NRI) is a complex pathological process of the interaction between the microenvironment of the host,body's microenvironment and pathogenic microorganisms.The molecular basis for the occurrence of NRI in Helicobacter pylori-related gastric disease(HPGD) is likely due to the functional disorder of inflammatory cytokines,chemokines and cells caused by an abnormal micro RNA molecule and an abnormality within the NF-κB signaling pathway which is a central component of inflammation.This article initially proposed the perspective of 'pathogenic-toxin caused malignant transformation' and discussed a possible relationship between the change in the inflammatory microenvironment that occurs during the process of the malignant evolution of HPGD and the features of different TCM syndromes.