青藤碱对类风湿关节炎发病机制中细胞因子和信号转导通路的影响

Effects of sinomenine on the pathogenesis of rheumatoid arthritis involving the cytokines and signal transduction pathway

类风湿关节炎是一种以慢性滑膜炎为特征的自身免疫性疾病。青藤碱治疗类风湿关节炎已取得显著的临床疗效,其作用机制可能包括:抑制TNF-α、IL-6、IL-1β、趋化因子等炎性细胞因子,调节Th17/Treg细胞比例失衡,上调IL-10,阻断过度活化的TLR受体及其上下游相关信号转导通路,诱导滑膜细胞凋亡等。

Rheumatoid arthritis is a kind of autoimmune disease characterized by chronic synovitis.Sinomenine has been shown remarkable curative effect on this disease.The mechanism may include:inhibiting inflammatory cytokines such as TNF-α,IL-6,IL-1β,chemokines,regulating the imbalance of Th17/Treg cells,upregulating the IL-10 level,blocking the overactivated TLR receptors and its related upstream and downstream signal transduction pathways,and inducing the apoptosis of synovial cell.