菟丝二仙汤对肾阳虚型弱精子症患者精子活力及精浆MDA和SOD的影响

Effects of Tusi Erxian Decoction on sperm motility, malondialdehyde and superoxide dismutase in seminal plasma of asthenospermia patients with syndrome of deficiency of kidney yang

目的:探讨菟丝二仙汤治疗肾阳虚型弱精子症的疗效及相关机制。方法:180例肾阳虚型弱精子症患者随机分为菟丝二仙汤组、右归丸组、西药组(辅酶Q10胶囊、维生素E、维生素C),每组60例,分别治疗3个月。比较各组治疗前后精液参数,检测精浆丙二醛(MDA)和超氧化物歧化酶(SOD)变化,比较临床疗效。结果:菟丝二仙汤组在改善a级精子、精子活力、精子活率明显优于右归丸以及西药组(P<0.01),同时其能显著降低精浆MDA浓度,提高精浆SOD水平(P<0.01);组间临床疗效比较,菟丝二仙汤对肾阳虚型弱精子症疗效明显优于右归丸组与西药组(P<0.05)。结论:菟丝二仙汤可以明显提高肾阳虚型弱精子症患者的精液质量,增强精子的抗氧化作用可能是其治疗弱精子症的机制之一。

Objective: To investigate the effects and mechanism of Tusi Erxian Decoction in treating asthenospermia with syndrome of deficiency of kidney yang. Methods: A total of 180 patients were included and randomly divided into 3 groups: Tusi Erxian Decoction group, Yougui Pills group, and the western medicine group(coenzyme Q10 capsule, vitamin E and vitamin C), 60 cases per group. Each group was treated by the corresponding drugs for 3 months. The sperm parameters, malondialdehyde(MDA) and superoxide dismutase(SOD) were detected to compare the clinical efficacy. Results: The Tusi Erxian Decoction could significantly improve a-level sperm, sperm motility and sperm activity when compared with the Yougui Pills group and the western medicine group(P<0.01). Meanwhile, Tusi Erxian Decoction could decrease the concentration of MDA and increase SOD in the seminal plasma(P<0.01). Clinical efficacy in the Tusi Erxian Decoction group was significantly better than that in the Yougui Pills group and the western medicine group(P<0.05). Conclusion: Tusi Erxian Decoction can improve the quality of sperm of asthenospermia patients with syndrome of deficiency of kidney yang by enhancing the antioxidant activity of spermatozoa.