光明盐四味汤散对非酒精性脂肪性肝病模型小鼠血脂及肝功能的影响

Effects of Guangmingyan Siweitang Powder on blood lipid and liver function in nonalcoholic fatty liver model mice

目的:观察蒙药光明盐四味汤散对非酒精性脂肪性肝病(NAFLD)模型小鼠血脂及肝功能的影响。方法:将小鼠造模后随机分空白组、模型组、硫普罗宁组和光明盐四味汤散组。模型组给予水和高脂饲料,硫普罗宁组给予硫普罗宁56mg/kg,光明盐四味汤组给予0.45g/kg光明盐四味汤散。灌胃4周后,眼眶采血,检测甘油三酯(TG)、胆固醇(TC)、谷丙转氨酶(ALT)、谷草转氨酶(AST)。结果:与模型组比较,光明盐四味汤散组血清TG、TC水平明显降低(P<0.05);两组血清ALT、AST比较差异无统计学意义。结论:光明盐四味汤散有明显降低NAFLD模型小鼠血清中的血脂作用,对肝脏保护功能虽无统计学意义,但也有一定的改善作用。

Objective: To observe the influence of Mongolian medicine Guangmingyan Siweitang Powder on blood lipid and liver function of nonalcoholic fatty liver mice. Methods: Mice were randomly divided into the model control group, the blank control, the tiopronin control group and the Guangmingyan Siweitang Powder group. Mice in the model control group were given water and high fat feed stuff; mice in the tiopronin control group were given 56mg/kg of tiopronin; mice in the Guangmingyan Siweitang Powder group were given 0.45g/kg of Guangmingyan Siweitang Powder. After intragastric administration for 4 weeks, the concentration of the serum triglyceride(TG), cholesterol(TC), alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were measured by extracting the eyeball blood. Results: Compared with the model control group, serum TG and TC in Guangmingyan Siweitang Powder group were significantly reduced(P<0.05); there were no significant differences in serum ALT and AST. Conclusion: Guangmingyan Siweitang Powder could obviously reduce the blood lipid in the serum of nonalcoholic fatty liver model mice. In spite of its protection of liver function has no statistical significance, it has the function of improvement to some extend.