慢性胃炎湿热证患者常见病位的口腔呼气气味图谱特征

Oral breath spectrum of common disease location in chronic gastritis patients with syndrome of damp heat

目的:运用电子鼻探讨慢性胃炎湿热证患者的口腔呼气气味图谱特征。方法:采用证素辨证的方法筛选出285例慢性胃炎湿热证患者并判断病位证素,运用基于阵列式气体传感器技术的医用电子鼻(EN0l1103-A)采集口腔呼气的气味图谱,选择气味图谱响应曲线的振幅、面积作为图谱特征参数,探讨慢性胃炎湿热证患者的口腔呼气气味图谱特征。结果:(1)慢性胃炎湿热证的主要病位证素分布是:胃90.2%,脾44.6%,肝23.5%;主要病位为胃、脾胃、肝脾胃;(2)胃湿热证与脾胃湿热证、肝脾胃湿热证的气味图谱响应曲线的振幅特征比较:肝脾胃组口腔呼气气味图谱曲线B、C、D、E、F、I、J显著高于胃组(P<0.05,P<0.01),肝脾胃组E、J高于脾胃组(P<0.05),胃组与脾胃组差异无统计学意义。(3)胃湿热证与脾胃湿热证、肝脾胃湿热证的气味图谱响应曲线的面积特征比较:肝脾胃组口腔呼气气味图谱曲线A、B、C、D、E、F、G、H、I、J显著高于胃组(P<0.01),G、J高于脾胃组(P<0.05),胃组与脾胃组差异无统计学意义。结论:运用电子鼻可初步判断慢性胃炎湿热证不同病位间的口腔呼气气味差异。

Objective: To explore the characteristics of oral breath spectrum in patients with chronic gastritis(CG) with syndrome of damp heat by electronic nose. Methods: A total of 285 cases of CG patients with syndrome of damp heat were selected and the disease locations were judged by syndrome elements differentiation method. Odor profiles of oral breath were collected by medical electronic nose EN0l1103-A based on array gas sensor array technology. The amplitude and area of the response curve of the odorprofiles were selected as the characteristic parameters to discuss oral breath odor fingerprint of CG patientswith syndrome of damp heat. Results:(1)The main disease location element distribution feature of damp heat syndrome in CG was: 90.2% in the spleen, 44.6% in the stomach and 23.5% in the liver; the major disease locations were stomach, spleen and stomach, liver and spleen stomach;(2)Comparison of response curves of different patients with damp heat syndrome in different disease locations: Amplitude feature comparison: The amplitude of the odor response pattern curve B, E, I, J of the mixture of liver, spleen and stomach group of CG patients with damp heat syndrome were significantly higher than those of the stomach group(P<0.01), C, D, F were higher than those of the stomach group(P<0.05), and E, J of the mixture of liver and spleen stomach group were higher than those of the mixture of spleen and stomach group(P<0.05). There was no significant difference between the stomach group and the mixture of spleen and stomach group;(3)The area feature comparison of the odor response pattern curves: A, B, C, D, E, F, G, I and H of the mixture of liver, spleen and stomach group of CG patients with damp heat syndrome were significantly higher than those of the stomach group(P<0.01), and G, J were higher than the mixture of spleen and stomach group(P<0.05); there was no significant difference between the stomach group and the mixture of spleen and stomach group. Conclusion: Electronic nose can be used to judge the oral breath smell differences of disease location in CG patients with syndrome of damp heatpreliminarily.