化疗所致周围神经病变外治法概述

Discussion on conception in external treatment of chemotherapy-induced peripheral neuropathy

化疗所致的周围神经病(CIPN)有可能导致化疗剂量减少和/或早期停止,同时可长期影响生活质量。现代医学多以冷冻、压迫等以造成局部缺血,降低外周化疗药物浓度,从而减少CIPN的发生率及严重程度。中医药防治化疗药物引起的周围神经病变研究多以针灸推拿、中药外敷、中药泡洗等,这些治疗法则多以活血、通络、养血、温阳等'热'为主,这与现代医学的'寒'有不一致之处。文章分析比较中西医对CIPN的研究后,提出在CIPN形成前,用现代医学的冷/压迫等'寒'的方法减少化疗药物在外周神经的分布,减少毒性;CIPN出现后,采用中医外治温通经脉的热/运动等'热'的方法缓解症状、加速康复。

Chemotherapy-induced peripheral neuropathy(CIPN)may lead to reduced chemotherapy doses and/or early cessation,while at the same time affecting quality of life in the long term.Modern medicine mostly uses freezing,compression to cause ischemia and reduce the concentration of peripheral chemotherapy drugs,reducing the incidence and severity of CIPN.Treatment of traditional Chinese medicine on CIPN are mostly acupuncture and massage,Chinese medicine soaking,etc.These treatment methods are mostly invigorate the circulation of blood,dredging collaterals,nourishing the blood,warming yang and other‘hot’treatment,compared with modern medicine‘cold’.This article analyzed and compared the research of CIPN between Chinese and western medicine and proposes to reduce the distribution of chemotherapeutic drugs in the peripheral nerves and reduce toxicity before the formation of CIPN with cold/compression techniques of modern medicine.And the‘hot’methods such as warming/moving through the meridians of traditional Chinese medicine are used to relieve symptoms and accelerate recovery.