基于临床研究数据的慢性阻塞性肺疾病急性加重风险因素的筛选

Screening of risk factors for acute exacerbation of chronic obstructive pulmonary disease based on clinical research data

目的:基于临床研究数据,采用多元统计学方法,筛选随访6个月、12个月慢性阻塞性肺疾病急性加重(AECOPD)的风险因素。方法:采用回顾性分析研究,对既往1 326例慢性阻塞性肺疾病稳定期患者研究前、随访6个月、随访12个月的研究数据进行清洗整理,采用频数分布、t检验、相关分析及Logistic回归分析等方法,分析AECOPD发生的风险因素。结果:随访6个月AECOPD发生的风险因素有:前1年急性加重次数、急性加重持续时间,mMRC,6MWD、FVC、ESQ-COPD工作生活能力、咳嗽、气短、乏力等;随访12个月AECOPD发生的风险因素有:前1年急性加重次数、急性加重持续时间,mMRC、6MWD、COPD-PRO临床症状、ESQ-COPD工作生活能力、咳嗽、气短、乏力等。结论:影响AECOPD发生的风险指标包括疾病相关情况(前1年急性加重次数、急性加重持续时间,mMRC,6MWD)、实验室检查(FVC)、生活质量(COPD-PRO临床症状、ESO-COPD工作生活能力)、临床症状(咳嗽、气短、乏力),针对性进行预防和干预,有望能够减少AECOPD的发生。

Objective:To screen the risk factors for acute exacerbation of chronic obstructive pulmonary disease with the follow-up period 6 months and 12 months based on clinical research data by multivariate statistical.Methods:The research were designed and study by retrospective analysis with frequency distribution,t test,correlation analysis and Logistic regression analysis.The risk factors of the AECOPD were analyzed with research data from the 1 326 chronic obstructive pulmonary disease in the stable period with the follow-up period 6 months and 12 months.Results:The risk factors for AECOPD at 6 months follow-up were acute exacerbations in the previous year,acute exacerbation duration,mMRC,6 MWD,FVC,work-life ability field for ESQCOPD,cough,shortness of breath,fatigue,etc.The risk factors for AECOPD at 12 months follow-up were acute exacerbations in the previous year,acute exacerbation duration,mMRC,6 MWD,clinical symptoms field for COPD-PRO,work-life ability field for ESQ-COPD,cough,shortness of breath,fatigue,etc.Conclusion:The Risk factors of AECOPD included disease-related conditions(acute exacerbations in the previous year,acute exacerbation duration,mMRC,6 MWD),laboratory tests(FVC),and quality of life(clinical symptoms field for COPD-PRO,work-life ability field for ESQ-COPD),clinical symptoms(cough,shortness of breath,fatigue).It would reduce the occurrence of AECOPD if targeted prevention and intervention for risk factors.