基于整合药理学策略的黄连解毒汤抗炎机制分析

Analysis on anti-inflammatory mechanism of Huanglian Jiedu Decoction based on integrated pharmacology strategy

目的:文章应用整合药理学平台对黄连解毒汤成分抗炎作用进行分析,预测黄连解毒汤的抗炎作用靶点以及通路。方法:对平台富集到的炎症相关的靶点、通路等进一步分析,旨在研究黄连解毒汤发挥抗炎作用的分子机制。结果:黄连解毒汤有效成分中的活性成分具有抗炎的作用;富集到的核心药物靶标NF-κB、STAT和PPAR与炎症反应的发生发展关系密切;主要通路包含氧化磷酸化、脂质代谢、线粒体等,可通过调控细胞内自由基、胆固醇、线粒体离子稳态等过程干预炎症。结论:采用整合药理学策略展开分析,有助于揭示黄连解毒汤抗炎作用的分子机制。

Objective:In this study,the integrated pharmacology platform was used to analyze anti-inflammatory effects of Huanglian Jiedu Decoction.Methods:The targets and pathways of Huanglian Jiedu Decoction were predicted,and the inflammation-related targets and pathways that enriched in it were further analyzed in order to study the molecular mechanism of Huanglian Jiedu Decoction in exerting anti-inflammatory effects.Results:The analysis results showed that the active ingredients in the active ingredients of Huanglian Jiedu Decoction had anti-inflammatory effects.The enriched core drug targets NF-κB,STAT and PPAR were closely related to the occurrence and development of inflammatory reactions.The main involved pathways included oxidative phosphorylation,lipid metabolism,mitochondria,etc.They could affect inflammation pathway through the regulation of intracellular free radicals,cholesterol,mitochondrial ion homeostasis and other processes.Conclusion:This project uses integrated pharmacology strategies to analyze and reveal molecular mechanisms of the anti-inflammatory effects of Huanglian Jiedu Decoction.