红皮云杉多酚体内抗肿瘤活性研究

Anti-tumor Activity of Polyphenol from Picea koraiensis Nakai in vivo

[目的]研究红皮云杉多酚的抗肿瘤效果。[方法]采用动物试验法,将S180细胞注射进小鼠体内,通过测定抑瘤率和免疫指标,分析其抗肿瘤效果。[结果]环磷酰胺的抑瘤率为73.20%,高剂量红皮云杉多酚的抑瘤率为61.31%,但环磷酰胺对机体免疫器官和抗氧化能力有不良影响,而红皮云杉多酚对免疫器官具有保护作用,并可以明显提高机体的抗氧化能力。[结论]红皮云杉多酚有显著的抗肿瘤作用,且安全性好。

[Objective] To study the anti-tumor activity of polyphenol from Picea koraiensis Nakai. [Method] S180 cell was injected into the mice. The anti-tumor effects were analyzed by detecting the anti-tumor rate and immune index. [ Result ] The anti-tumor rate of cyclophosphamide （CTX） was 73.2%, that of high-dosage P. koraiensis polyphenol was 61.31%. However, CTX had harmful effects on the body＇s immune organs and oxidation resistance. And P. koraiensis polyphenol showed protection effects on immune organs and could significantly enhance the activity of antioxidant. [ Conclusion] P. koraiensis polyphenol is safe and has significant anti-tumor effects.