MDR1基因多态性及其临床相关性

MDR1 polymorphisms and clinical relevance

P-糖蛋白作为一种广泛分布于全身各组织和器官的重要转运体,对多种药物在体内的吸收、分布、代谢、排泄过程以及防止有害外源性物质的侵袭起重要作用。作为P-糖蛋白的编码基因,多药耐药基因(multidrug resistance-1,MDR1)的多态性在一定程度上决定了上述过程在个体与个体之间的差异,因此对许多疾病的易感性以及特定药物在体内的药动学,药效学和治疗效应均存在较大影响。本文将对MDR1基因多态性对疾病易感性和临床上药动、药效学过程的影响进行综述。

P-glycoprotein is widely distributed throughout the tissues and organs of the human body. As an important transporter,it plays a significant role in the absorption,distribution,metabolism and excretion of many drugs and the protection of the human body from harmful exogenous substances.Multidrug resistance gene（ MDR1） encodes P-gp,and its genetic polymorhisms determine the interindividual differences of those processes. Therefore,the genetic polymorphisms of MDR1 have a profound effect on the pharmamocogetic processes and therapeutic effects of certain drugs as well as the susceptibility of many diseases,which are reviewed in this paper.