精神分裂症和情感性精神病患者血浆腺苷脱氨酶的活性

Activities of adenosine deaminase of plasm in schizophrenic and affective patients.

本研究测定了精神分裂症和情感性精神病患者治疗前血ADA活性,结果与正常人比较无显著差异。经抗精神病药或抗抑郁药治疗后,精神分裂症患者,主要是衰退型患者,血ADA活性与治疗前相比明显降低,而双相和非核心型抑郁症患者的血ADA活性则比治疗前明显升高。这些变化可能同药物引起的T淋巴细胞的功能改变有关。

Adenosine deaminase (ADA) activi-ies of schizophrenic(73), tnanic(31) and depressive(75) Patients were determined before the treatment and Compared with those of 38 normal subjects It was shown that no significant differences were found between the Patient group and the control group. After the patients were cured with the antipsychotics or antidepressants, the ADA activities of schizophrenics were much lower than those of untreated ones, especially the involutional type (P<0.05). After the depressive patients were treated with tricyclic antidepressants, ADA activities of bipolar and nonuclear depressive patients were much higher than those of untreated depressive cases (p<0.05 and P<0.01, respectively). The changes of ADA activity in the schizophrenic and depressive patients may be related to the changes of T-cell function caused by the medicines.