干扰素联合丙种球蛋白对儿童传染性单核细胞增多症的疗效评价

Discussions about the clinical value of interferon plus gamma globulin for the children with infectious mononucleosis

目的探讨传染性单核细胞增多症(IM)的治疗方法。方法 125例传染性单核细胞增多症患儿分为3组,选用干扰素(A组),干扰素加病毒唑(B组),干扰素加丙种球蛋白(C组)3种治疗方案。比较各组有效率、临床症状、体征的变化。结果 C组临床症状及体征均较A、B组消失快(P<0.05)。3组有效率分别为74.42%、85.0%、97.62%,A组和C组有效率有统计学意义(P<0.05)。结论应用干扰素联合丙种球蛋白治疗儿童传染性单核细胞增多症是一种安全、疗效肯定的治疗方案,可以明显提高儿童传染性单核细胞增多症的治疗效果。

Objective To explore the clinical value of interferon plus gamma globulin for the children with infectious mononucleosis（IM）.Methods 125 patients with infectious mononucleosis were randomly divided into A group treated with interferon alone,B group treated with interferon combined with virazole,and C group treated with interferon plus gamma globulin.The effective rate,clinical symptoms and signs were compared among the three groups.ResultsThe clinical symptoms and signs of the patients in C group disappeared earlier than those in the A and B group（P〈0.05）.The total effective rate of A group,B group and C group were 74.42%,85.0%and 97.62%.The total effective rate of Group A was different from that of Group C（P〈0.05）.Conclusion Interferon plus gamma globulin is a safe and effective method for infectious mononucleosis,which can be used to raise the curative rate in children with IM.