醒脑静注射液穴位注射对慢性阻塞性肺疾病的影响

Influence of acupoint injection with Xingnaojing Injection on chronic obstructive pulmonary disease

目的观察醒脑静注射液穴位注射对慢性阻塞性肺疾病的影响。方法选取2015年1月~2016年1月山东中医药大学附属医院保健科及肺病科病房收治的120例慢性阻塞性肺疾病急性加重期（AECOPD）患者,随机分为对照组30例、穴位注射组（以下简称＂穴注组＂）30例、静脉滴注组（以下简称＂静点组＂）30例、穴位针刺组（以下简称＂针刺组＂）30例,疗程均为2周。观察各组临床疗效、治疗前后肺功能及血清中枢神经肽（Orexin）A、白介素（IL）-17及降钙素原（PCT）水平。结果穴注组临床疗效明显优于针刺组和对照组（P〈0.05）。穴注组治疗后第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC明显高于针刺组和对照组,口腔闭合压（P0.1）及血清Orexin A、PCT、IL-17水平明显低于针刺组和对照组,差异有统计学意义（P〈0.05）。穴注组与静点组临床疗效及治疗后FEV1、FVC、FEV1/FVC、P0.1及血清Orexin A、PCT、IL-17水平比较,差异无统计学意义（P〉0.05）。结论醒脑静注射液穴位注射能明显改善AECOPD患者的肺功能,降低炎性反应,控制感染,疗效显著。

Objective To observe influence of acupoint injection with Xingnaojing Injection on chronic obstructive pulmonary disease. Methods 120 patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）treated in Geriatrics and Respiratory Department Ward, Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2015 to January 2016 were selected and randomly divided into four groups： 30 cases of control group, 30 cases of acupoint injection group, 30 cases of intravenous drip group and 30 cases of acupoint acupuncture group. After 2 weeks treatment course, clinical effect, lung function, Orexin A, IL-17, PCT levels before and after treatment among four groups were observed. Results Clinical effect in acupoint injection group was better than those in acupoint acupuncture group and control group（P〈0.05）. After treatment, FEV1, FVC, FEV1/FVC in acupoint injection group were higher than those in acupoint acupuncture group and control group, P0.1, Orexin A, PCT,IL-17 levels in acupoint injection group were lower than those in acupoint acupuncture group and control group, with statistical differences（P〈0.05）. Clinical effect, FEV1, FVC, FEV1/FVC, P0.1, Orexin A, PCT, IL-17 levels after treatment in acupoint injection group and intravenous drip group were compared, with no statistical difference（P〈0.05）.Conclusion Acupoint injection with Xingnaojing Injection can significantly improve pulmonary function of AECOPD patients, alleviate inflammatory response and control infection, curative effect is remarkable.