一种应用于质谱仪的离子传输效率测量技术

Measurement Technology of Ion Transport Efficiency for Mass Spectrometry

质谱仪在食品安全、环境安全及临床制药等领域的应用越来越广泛与深入，对其检测的灵敏度要求也越来越高，提升灵敏度也成为质谱仪发展的一个重要方向。提升灵敏度关键在于设计高传输效率的离子光学系统，而如何测量离子光学系统的传输效率，即确定离子在离子光路系统中的哪个环节损失是一项至关重要的一项研究。因此设计一种精确测量离子光学系统离子流传输效率的测量技术，对开发质谱仪具有重要的指导意义。本文利用带电荷离子定向流动形成电流的原理，设计一种收集并测量离子流的测量系统从而得到离子数量，并使用该测量系统实际测试了三重四极杆串联质谱仪离子光学系统的传输效率，测试结果与理论结果符合。

Mass spectrometry has been employed more and more widely and deeply in the field of food safety, environmental safety and clinical pharmacy, and the higher sensitivity will play an important role in some application cases in the future, as a result, to achieve higher sensitivity has become an important focal point in the development of mass spectrometers. In order to enhance the sensitivity it is needed to design an ion optical system with better transmission efficiency, the research that how to measure the ion transmission efficiency, or how to determine where the ion loss in the ion optics, has become more and more important. So it is quite necessary to design an accurate measurement method for measuring the ion transmission efficiency when developing mass spectrometers. A method to determine the ion pupulations in the ion optics has been developed, and in the method, the current that formed by the ions collected on the probe was measured and thus ion populations could be calculated according to the relationship between ion populations and current. The method was utilized to determine the ion transmission efficiency in the ion optics of triple quadrupole mass spectrometer, and the results were in line with the theoretically calculated results