益气养阴活血化瘀法治疗2型糖尿病临床研究

Clinical Study of the Method of Tonifying Qi and Yin and Removing Blood Stasis in Treatment of Type 2 Diabetes

目的:观察益气养阴活血化瘀法联合瑞格列奈及二甲双胍治疗2型糖尿病患者的疗效。方法:90例2型糖尿病患者根据数字表法随机分为对照组和观察组,每组45例,对照组给予常规治疗,观察组给予益气养阴活血化瘀法联合瑞格列奈及二甲双胍进行治疗。治疗3个疗程后,比较两组患者的胰岛素抵抗(insulin resistance,IR)和胰岛β细胞功能,比较两组患者的血糖、糖化血红蛋白、低血糖事件发生率以及不良反应发生情况。结果:治疗后,与治疗前相比两组患者的IR均有所改善,且差异具有统计学意义(P<0.05)。与治疗前比较,两组患者的胰岛β细胞细胞功能均有所改善,且差异具有统计学意义(P<0.05);观察组患者的胰岛β细胞细胞功能改善情况显著优于对照组,且差异具有统计学意义P<0.05)。治疗后,与治疗前相比两组患者的空腹血糖均有所改善,且差异具有统计学意义(P<0.05);观察组患者空腹血糖浓度显著低于对照组,且差异具有统计学意义(P<0.05)。与治疗前比较,两组患者的餐后血糖均有所改善,且差异具有统计学意义(P<0.05);观察患者的餐后血糖显著低于对照组,且差异具有统计学意义(P<0.05)。观察组患者轻度低血糖的发生率和低血糖发生例数显著低于对照组,且差异具有统计学意义(P<0.05)。观察组患者发生腹胀、腹泻、口干、便秘等不良反应的比例显著低于对照组,且差异具有统计学意义(P<0.05)。结论:益气养阴活血化瘀法联合瑞格列奈及二甲双胍对可有效改善2型糖尿病患者胰岛β细胞细胞功能,改善低血糖的发生率,降低不良反应发生率。

Objective： To observe the clinical efficacy of the method of tonifying Qi and Yin and removing blood stasis combined with Repaglinide and Metforminin in treatment of type 2 diabetes. Methods： 90 cases of patients with type 2 diabetes were randomly divided into control group and observation group,with 45 cases in each group. The control group received routine Western medical treatment,while the observation group received with the method of tonifying Qi and Yin and removing blood stasis combined with Repaglinide and Metforminin. After 3 courses of treatment,two groups were compared in insulin resistance（ IR） and islet β cell function,blood glucose,glycated hemoglobin,the incidence of hypoglycemic events and adverse events. Results： After treatment,the IR,islet β cells function,the fasting blood glucose,the fasting plasma glucose concentrations and the postprandial blood glucose of the two groups of patients have been improved and the differences between the two groups were statistically significant（ P〈0. 05）. The incidence of hypoglycemia,bloating,diarrhea,dry mouth,constipation and other side effects of the two groups were significantly lower than before and the differences between the two groups were statistically significant（ P〈0. 05）. Conclusion： The method of tonifying Qi and Yin and removing blood stasis combined with Repaglinide and Metforminin in treatment of type 2 diabetes is clinical effective in improving patients＇ β cells function and reducing the incidence of low blood sugar and adverse reactions.