乙酰辅酶A羧化酶在内分泌代谢性疾病中的作用

The role of Acetyl-CoA carboxylase in endocrinal and metabolic disease

乙酰辅酶A羧化酶（ACC）是脂肪酸合成的限速酶，ACC可以催化乙酰辅酶A生成丙二酰辅酶A，而后者作为长链脂肪酸合成的前体，既为脂肪酸合成提供供体，又可变构抑制脂肪酸转运至线粒体氧化，因此ACC在脂肪酸合成和代谢中发挥至关重要的作用。因其特殊的生物学功能，ACC在肥胖、非酒精性脂肪性肝病、糖尿病、高尿酸血症等内分泌代谢性疾病中的作用日趋重要，可成为多种代谢性疾病潜在的治疗靶点。

Acetyl-CoA carboxylase（ACC） is a speed limit enzyme of fatty acid synthesis. It cataly- zes acetyl-CoA to generate malony CoA, which is the precusor of the long chain fatty acid. Furthermore, ma- lony CoA can not only provide donor for fatty acid synthesis, but also as an allosteric inhibitor of fatty acid transport into mitochondria for oxidation. Therefore, ACC plays an vital role in fatty acid synthesis and me- tabolism. Because of its special biological functions, ACC plays an increasingly important role in obesity, nonalcoholic fatty liver disease, diabetes, hyperuricemia and can be a potential therapeutic target of metabol- ic diseases.