血尿酸与糖尿病肾病被引量：6

Serum uric acid and diabetic nephropathy

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摘要血尿酸是嘌呤代谢的最终产物。近年来许多大型观察性队列研究已证实，血尿酸与糖尿病肾病的发生、发展密切相关。其主要机制包括内皮功能紊乱，肾素一血管紧张素一醛固酮系统过度激活及炎性瀑布反应等。别嘌呤醇、非布司他及某些调脂、降血压药物等干预糖尿病肾病高尿酸的药物，可以作为传统糖尿病肾病治疗的一种补充。 Serum uric acid is an end product from purine derivatives. Large observational cohort studies in recent years have demonstrated serum uric acid was correlated with the occurrence and develop- ment of diabetic nephropathy. The main mechanism mainly includes endothelial dysfunction, increased activ- ity of renin-angiotensin-aldosterone system （RAAS） and induction of inflammatory cascades. Interventions of diabetic nephropathy along with high uric acid, such as allopurinol, febaxostat and some lipid-lowering and antihypentensive drugs, can complement traditional treatment of diabetic nephropathy.

作者周宇柯甦捷刘礼斌

机构地区福建医科大学附属协和医院内分泌科

出处《国际内分泌代谢杂志》 2016年第3期202-205,共4页 International Journal of Endocrinology and Metabolism

关键词尿酸糖尿病肾病高尿酸血症 Uric acid Diabetic nephropathy Hyperuricemia

分类号 R587.2 [医药卫生—内分泌]

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