中青年原发性高血压病患者炎性因子与踝臂指数的相关分析

Correlation Between Inflammatory Factors and Ankle- brachial Index of Young and Middle-aged Patients With Essential Hypertension

目的探讨中青年原发性高血压病患者炎性因子与踝臂指数(ABI)的相关关系。方法选取2012年1—12月从首都医科大学附属北京安贞医院高血压科出院的中青年原发性高血压病患者256例。记录患者入院时性别、年龄、身高、体质量、腹围、24 h收缩压(24 h SBP)、踝臂指数(ABI)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、血清清蛋白(Alb)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、同型半胱氨酸(Hcy)。炎性因子与ABI及其可能影响因素的相关分析采用Pearson相关分析,ABI的影响因素分析分别采用单因素和多因素线性回归分析。结果 ABI与年龄、男性腹围、24 h SBP、Ln LDL-C、UA、Ln FPG、Lnhs-CRP、WBC呈线性负相关(P<0.05)。单因素线性回归分析显示,年龄、男性腹围、24 h SBP、Ln LDL-C、UA、Ln FPG、Lnhs-CRP、WBC是ABI的影响因素(P<0.05)。Lnhs-CRP与年龄、男性腹围、Ln LDL-C、UA、Ln FPG、WBC呈线性正相关(P<0.05);WBC与年龄、24 h SBP、Ln LDL-C、UA呈线性正相关(P<0.05);Alb与ABI各影响因素均无线性相关关系(P>0.05)。多因素线性回归分析显示,年龄、24 h SBP、UA、WBC是ABI的影响因素(P<0.05)。结论中青年原发性高血压病患者hs-CRP、WBC与ABI有关,WBC是ABI的危险因素。

Objective To investigate the correlation between inflammatory factors and ankle- brachial index（ ABI） of young and middle- aged patients with essential hypertension. Methods We enrolled 256 young and middle- aged patients with essential hypertension who were discharged from Department of Hypertension of Beijing Anzhen Hospital from January to December in 2012. Gender, age, height, body weight, abdominal girth, 24 h SBP, ABI, hs-CRP, WBC, Alb, FPG, TC, TG,HDL-C,LDL-C,UA and Hcy of patients were recorded at admission. The correlation between inflammatory factors and ABI as well as its influencing factors was explored by Pearson correlation analysis,and the influencing factors for ABI were explored by univariate and multivariate linear regression analysis. Results ABI had negative linear correlation with age, male abdominal girth,24 h SBP,Ln LDL-C,UA,Ln FPG,Lnhs-CRP and WBC（ P〈0. 05）. Univariate linear regression analysis showed that age,male abdominal girth,24 h SBP,Ln LDL-C,UA,Ln FPG,Lnhs-CRP and WBC were the influencing factors for ABI（ P〈0. 05）. Lnhs-CRP had positive correlation with age,male abdominal girth,Ln LDL-C,UA,Ln FPG and WBC（ P〈0. 05）;WBC had positive correlation with age,24 h SBP, Ln LDL-C and UA（ P〈0. 05）; Alb had no linear correlation with the influencing factors for ABI（ P〉0. 05）. Multivariate linear correlation analysis showed that age,24 h SBP,UA and WBC were influencing factors for ABI（ P〈0. 05）. Conclusion hs-CRP and WBC in young and middle- aged patients with essential hypertension have correlation with ABI,and WBC is a risk factor for WBC.