不同剂量肉毒素A注射治疗神经源性逼尿肌过度反射患者的有效性

Efficacy of different dose of Botulinum toxin A in treatment of patients with neurogenic detrusor overactivity

目的研究不同浓度肉毒素A注射治疗脊髓损伤或者多发性硬化症所导致的神经源性逼尿肌过度反射的作用。方法统计我院2011年6月至2014年12月收治的43例由脊髓损伤或者多发性硬化症所导致的神经源性逼尿肌过度反射患者,完成12周的随访时患者总数为38例,其中20例患者给予200 U剂量的肉毒素A(200 U组),18例患者给予100 U剂量的肉毒素A(100 U组)。38例患者的平均年龄为45.3岁,女性比例高于男性。随访并记录6周及12周后尿失禁患者生活质量(I-QOL)评分相对于基线评分的变化。结果随访结束后,总体I-QOL得分的比较显示,200 U组患者明显高于100 U组,差异具有统计学意义(P<0.05)。结论肉毒素A注射治疗神经源性逼尿肌过度反射有一定的效果,而且200 U的剂量效果强于100 U。

Objective To research the efficacy of different dose botulinum toxin A in the treatment of patients with neurogenic detrusor overactivity due to spinal cord injury or multiple sclerosis. Methods The datas of 43 patients with neurogenic detrusor overactivity caused by spinal cord injury or multiple sclerosis which accepted treatment in our hostipal were analyzed. And 38 patients were followed up for 12 weeks,of which 20 cases were treated with 200 U botulinum toxin A,and 18 cases received 100 U botulinum toxin A. The average age of 38 patients was 45. 3 years old,and the ratio of famale was higher. The incontinence quality of life（ I-QOL） changed from baselin after 6 weeks and 12 weeks was recorded. Resluts The final outcomes showed that the efficacy of botulinum toxin A with 200 U was better than that with100 U according to I-QOL score,and the difference was statistical significance（ P 0. 05）. Conclusion The botulinum toxin A has positive effect on neurogenic detrusor overactivity,and the efficacy of 200 U injection is better than that of 100 U.