血清维生素A水平与儿童社区获得性肺炎相关性的初步研究

The Preliminary Study of the Vitamin A Level and Children with Community-acquired Pneumonia

目的：本研究旨在评估社区获得性肺炎患儿急性期、恢复期血清维生素A状况，探讨不同病原体肺炎患儿体内维生素A水平。方法：选择年龄为6个月~5岁（60个月）的不同病原体住院肺炎患儿152例为研究对象，并选择同期同一年龄门诊健康体检儿童50例为正常对照组，分别采用测定血清视黄醇（retinol）浓度的方法来评估患儿体内维生素A状况。结果：肺炎患儿血清VA低于正常对照组儿童[（0.87±0.34）μmol/L vs （1.18±0.23）μmol/L，P〈0.05]；不同病原体肺炎急性期血清VA水平不同，病毒性肺炎为（0.89±0.17）μmol/L、细菌性肺炎为（0.84±0.19）μmol/L、肺炎支原体肺炎为（0.73±0.15）μmol/L，其中肺炎支原体肺炎患儿血清VA水平相对较低，与细菌性肺炎组和病毒性肺炎组相比，差异有统计学意义（P〈0.05）。结论：社区获得性肺炎患儿血清VA水平较正常对照组下降，肺炎支原体肺炎患儿更易发生亚临床VA缺乏。

Objective：To analyze the vitamin A concentration in the acute and recovery phase of younger children with the community-acquired pneumonia,discuss the relationship of vitamin A concentration with different pathogens.Method：152 cases of children with community-acquired pneumonia aged from six months to five years（60 months） were selected as the research group and 50 healthy children of the same age were selected as the control group.The serum level of retinol was measured to analyze the vitamin A concentration.Result：The serum level of VA in the acute phase of pneumonia children was lower than the normal children[（0.87±0.34）μmol/ vs （1.18±0.23）μmol/L,P〈0.05] and different pathogens of acute pneumonia were at different levels,viral pneumonia was （0.89±0.17）μmol/L,bacterial pneumonia was （0.84±0.19）μmol/L,mycoplasma pneumonia was （0.73±0.15）μmol/L.Mycoplasma pneumonia in which the serum level of VA was relatively lower,compared with bacterial pneumonia and viral pneumonia,the differences were significant（P〈0.05）.Conclusion：The serum level of VA in community-acquired pneumonia children decreases compared with normal group and children with mycoplasma pneumonia are more likely to occur subclinical vitamin A deficiency.