不同剂量阿托伐他汀与辛伐他汀治疗老年冠心病合并高脂血症的效果观察

Comparison of the Clinical Effects of Different Doses of Atorvastatin and Simvastatin in the Treatment of Elderly Patients with Coronary Heart Disease Combined with Hyperlipidemia

目的:探讨不同剂量阿托伐他汀与辛伐他汀在老年冠心病合并高脂血症患者中的治疗效果。方法:112例老年冠心病合并高脂血症患者以数字表法随机分为A组(n=38)、B组(n=39)、C组(n=35)三组,A组给予阿托伐他汀10 mg/d治疗,B组给予阿托伐他汀20 mg/d治疗,C组给予辛伐他汀20 mg/d治疗,对比三组患者临床效果。结果:治疗后三组TC、TG、LDL-C均显著降低(P<0.01),HDL-C均显著增高(P<0.01);治疗后C组HDL-C显著低于A组、B组(P<0.01),B组TC、TG、LDL-C均显著低于A组、C组(P<0.01);三组治疗前后肝肾功能无明显变化(P>0.05)。结论:阿托伐他汀与辛伐他汀均能够有效降低冠心病合并高脂血症患者的血脂水平,以阿托伐他汀20 mg/d临床疗效最优,安全有效,值得推广。

Objective：To discuss the clinical effects of different doses of Atorvastatin and Simvastatin in the treatment of elderly patients with CHD combined with hyperlipidemia.Method：112 elderly patients with CHD combined with hyperlipidemia were randomly divided into group A（n=38）, group B（n=39）, and group C（n=35）,group A was treated with Atorvastatin 10 mg/d,group B was treated with Atorvastatin 20 mg/d,group C was treated with Simvastatin,then the clinical effects were contrasted between the three groups.Result：After treatment,TC,TG,and LDL-C were significantly lower,HDL-C was significantly higher than before treatment in the three groups（P〈0.01）.HDL-C in group C was significantly lower than group A and group B（P〈0.01）.TC,TG,LDL-C in group B were significantly lower than group A and group C（P〈0.01）.There was no significantly difference in liver and kidney function between the three groups before and after the treatment（P〉0.05）.Conclusion：Atorvastatin and Simvastatin can effectively reduce the lipid levels in elderly patients with coronary heart disease combined with hyperlipidemia,Atorvastatin 20 mg/d has the best clinical efficacy,and it’s safe and effective,worthy of promotion.