期刊文献+

视网膜小胶质细胞在年龄相关性黄斑变性中的免疫调节作用 被引量:8

The immunomodulatory role of retinal microglial cells in age-related macular degeneration
原文传递
导出
摘要 AMD是老年人的主要致盲眼病之一。近年来研究发现,视网膜小胶质细胞在AMD的发病中扮演了重要角色,其活化和极化状态可以影响病程的发展。本文就视网膜小胶质细胞对AMD的免疫调节作用进行综述,以期探讨其发生机制,为AMD的防治提供新的思路。 Age-related maeular degeneration (AMD) is one of the major causes of visual impairment in the elder population. Recent studies have revealed that retinal microgliaeytes may play an important role in the pathogenesis of AND, and the activation of retinal mieroglia could regulate the progress of AND. The immunomodulatory role of retinal microglial cells is reviewed in this article, so as to investigate the mechanism and provide new insight for prevention and treatment of AND.
出处 《中华眼科杂志》 CAS CSCD 北大核心 2016年第5期386-390,共5页 Chinese Journal of Ophthalmology
关键词 黄斑变性 视网膜 小神经胶质细胞 免疫调节 Macular degeneration Retina Microglia Immunomodulation
  • 相关文献

参考文献32

  • 1Zarbin MA, Casaroli-Marano RP, Rosenfeld PJ. Age-related macular degeneration: clinical findings, histopathology and imaging techniques[J]. Dev Ophthalmol, 2014, 53: 1-32.
  • 2Kawasaki R, Yasuda M, Song S J, et al. The prevalence of age- related macular degeneration in Asians: a systematic review and meta-analysis[J]. Ophthalmol, 2010, 117(5): 921-927.
  • 3Xu L, Wang S, Li Y, et al. Retinal vascular abnormalities and prevalence of age-related macular degeneration in adult Chinese: the Beijing Eye Study[J]. Am J Ophthalmol, 2006, 142(4): 688-689.
  • 4Ardeljan D, Chan CC. Aging is not a disease: distinguishing age-related macular degeneration from aging[J]. Prog Retin Eye Res, 2013, 37: 68-89.
  • 5Madeira MH, Boia R, Santos PF, et al. Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases[J]. Mediators Inflamm, 2015, 2015: 673090.
  • 6Karlstetter M, Scholz R, Rutar M, et al. Retinal microglia: just bystander or target for therapy?[J]. Prog Retin Eye Res, 2015, 45: 30-57.
  • 7Czeh M, Gressens P, Kaindl AM. The yin and yang of microglia[J]. Dev Neuro sci, 2011, 33 (3-4): 199-209.
  • 8Tsai M, Grimbaldeston M, Galli SJ. Mast cells and immunoregulation/immunomodulation[J]. Adv Exp Med Biol, 2011,716:186-211.
  • 9Ransohoff RM, Cardona AE. The myeloid cells of the central nervous system parenchyma[J]. Nature, 2010, 468(7321): 253- 262.
  • 10Chen L, Yang P, Kijlstra A, et al. Distribution, markers, and functions of retinal microglia[J]. Ocul Immunol Inflamm, 2002, 10(1): 27-39.

二级参考文献10

共引文献26

同被引文献45

引证文献8

二级引证文献42

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部