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三个喹啉银(Ⅰ)配合物的抗肿瘤活性研究 被引量：1

Study on the Antitumor Mechanism of Three Quinoline-based Silver(Ⅰ) Complexes
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摘要 采用MTT法测定配合物1~3对5种肿瘤细胞株（T-24、SK-OV-3、SK-OV-3/DDP、BEL-7402、HCT-8）和1种人正常肝细胞HL-7702进行体外活性测试,并利用琼脂糖凝胶电泳实验初步探讨了配合物1~3与p UC19 DNA相互作用。实验结果表明,相对于正常细胞HL-7702,配合物1~3对5种肿瘤细胞的生长均表现出不同程度的抑制作用,其IC50范围为5.7~40.1μM。同时,研究还发现配合物1~3以插入作用方式与DNA作用。 The antitumor activity of quinoline-based silver（I） complexes 1~3 against T-24, SK-OV-3, SK-OV-3/DDP, BEL-7402, HCT-8 tumor cell lines and human normal liver cell line HL-7702 were screened by MTT assay. The binding mode of 1~3 with p UC19 plasmid DNA was examined by agarose gel electrophoresis assay. The results indicated 1~3 exhibit selective cytotoxicity against-24, SK-OV-3, SK-OV-3/DDP, BEL-7402, HCT-8 cell lines with IC50 values generally in the micromolar range（5.7~40.1 μM）, but low cytotoxicity towards normal human liver cell HL-7702. The interactions of 1~3 with DNA are most probably via an intercalation.
作者 蒙婷 覃其品 张运良 伍宸旋 梁月兰
机构地区 广西师范大学化学与药学学院 邵阳医学高等专科学校药学系
出处 《广东化工》 CAS 2016年第9期50-51,共2页 Guangdong Chemical Industry
基金 广西研究生教育创新计划项目(YCBZ2015024) 2014年湖南省科技厅项目湘财企[2014]2号(2014FJ3012) 广西师范大学重点实验开放室课题(CMEMR2014-B13) 2014年湘中医药[2014]13号(2014107) 2013年湖南省教育厅教改项目湘教通[2013]223号(SJ641)
关键词 银(Ⅰ)配合物 抗肿瘤活性 MTT法 插入作用 琼脂糖凝胶电泳 silver（Ⅰ） complex antitumor activity MTT assay intercalation agarose gel electrophoresis assay
分类号 Q523.03 [生物学—生物化学]
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参考文献11

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同被引文献10

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广东化工
2016年 第9期

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