地氯雷他定联合雷公藤多甙片治疗慢性特发性荨麻疹疗效研究

Clinical curative effect of desloratadine combined with tripterygium glycosides on chronic idiopathic urticaria

目的探究地氯雷他定联合雷公藤多甙片治疗慢性特发性荨麻疹的临床疗效。方法选择深圳市第七人民医院2013年4月至2014年12月接诊的120例慢性特发性荨麻疹患者,随机分为观察组和对照组,每组60例。对照组给予单用地氯雷他定治疗,观察组给予地氯雷他定联合雷公藤多甙片治疗,观察两组的临床疗效。结果观察组治疗有效率为83.33%,高于对照组53.33%,差异有统计学意义(P<0.05);观察组生活质量改善率为90.00%,高于对照组(71.67%),差异有统计学意义(P<0.05);两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论地氯雷他定联合雷公藤多甙片治疗慢性特发性荨麻疹具有良好的疗效,能明显改善患者生活质量,且不增加不良反应,值得临床推广。

Objective To study the clinical curative effect of desloratadine combined with tripterysium glycosides on chronic idiopathic urticaria. Methods One hundred and twenty patients with chronic idiopathic urticaria in the Seventh People＇ s Hospi- tal of Shenzhen from April 2013 to December 2014 were selected and divided into observation group and control group with sixty patients in each group. The control group was given desloratadine and the control group was given desloratadine and tripterysium glycosides. The efficacy of the two groups was compared. Results The effective rate of observation group was 83.33 %, and the effective rate of control group was 53.33% （P 〈 0. 05）. 90.00% patients of observation group had better quality of life, and 71.67% patients of control group had better quality of life （ P 〈 0. 05 ）. There was no significant difference in the rate of side effects between the two groups （P 〉 0. 05）. Conclusion Tripterygium glycosides combined with desloratadine has a better effi- cacy, and they can improve the quality of life without increase in side effects.