女性阴道炎患者沙眼衣原体感染状况调查分析

Investigation and analysis of female vaginitischlamydia trachomatis infection

目的：分析女性阴道炎患者沙眼衣原体感染以及耐药性状况。方法：选择2009年11月至2014年11月期间收治的126例女性阴道炎患者为研究对象,采用宫颈分泌物立明法检查所有阴道炎患者沙眼衣原体（CT）的阳性率,并采用Kiby-Bauer药敏纸片法对CT进行简单的耐药性分析。结果：经过宫颈分泌物立明法分析,36例念珠菌性阴道炎的CT阳性率为13.9%,34例滴虫性阴道炎的CT阳性率为17.6%,21例细菌性阴道炎的CT阳性率为14.2%;35例非淋菌性阴道炎的CT阳性率为22.9%。126例患者的CT检出率为17.5%,四种类型的阴道炎患的CT阳性率无显著性差异（P〉0.05）;经过宫颈分泌物立明法分析,20~40岁组阴道炎患者CT阳性率为17.3%,41~60岁组阴道炎患者CT阳性率为17.6%。不同年龄分组的阴道炎患者的CT阳性率无显著性差异（P〉0.05）;经过Kiby-Bauer药敏纸片法分析,CT对磺胺醋酰钠的耐药性最高,其次是氯霉素与四环素;对35株CT临床株进行药敏实验分析,仅有1株对阿奇霉素产生耐药性,耐压率为2.9%,因此,使用阿奇霉素治疗CT感染具有较好的临床效果。结论：不同类型、不同年龄组的女性阴道炎的沙眼衣原体（CT）的阳性率差异性不大,阳性率均较高。对阴道炎患者进行耐药性实验,可对临床治疗进行一定的指导。

Objectives： To analyze the situation of female vaginitis chlamydia trachomatis infection and drug resistance. Methods： 126 vaginitis patients admitted from November 2009 to November 2014 were selected and the chlamydia trachomatis（ CT） positive rate was tested using cervical secretions liming method. Simple drug resistance test was conducted using Kiby- Bauer disk diffusion method in all the detected chlamydia trachomatis. Results：The CT positive rate of the 36 patients with candida vaginitis was 13. 9%; the CT positive rate of the 34 patients with trichomonas vaginitis was 17. 6%; the CT positive rate of the 21 patients with bacterial vaginosis was 14. 2%;the CT positive rate of the 35 patients with non- gonococcal vaginitis was 22. 9%. The total CT detection rate in the126 patients was 17. 5%,without significant difference between the four groups（ P〉0. 05）. The CT positive rate in 20- 40 year- old group was 17. 3% and 17. 6% in the 40- 60 years old group,without significant difference between different age group（ P〉 0. 05）. According to Kiby- Bauer disk diffusion method,the resistance of chlamydia trachomatis against sulfacetamide sodium was the highest,followed by chloramphenicol and tetracycline.According to the susceptibility testing of the 35 clinical isolates of C. trachomatis,only a case had azithromycin resistance（ 2. 9%）. Therefore,the use of azithromycin in the treatment of chlamydia trachomatis infection had better clinical results. Conclusion： The CT positive rate of vaginitis women at different ages or types is not significantly different,and drug resistance testing is useful in guiding clinical treatment.