摘要
As the fifth most common cancer and the third most comxnon cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of AT. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-r,B, mitogen-acfivated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.
胃癌是全球最常见的恶性肿瘤之一,发病率和死亡率分别居于第五和第三,不仅危害着人类的健康,也给人类带来了很大的经济负担。幽门螺旋杆菌感染导致胃部炎症的发生,长期的炎症刺激导致胃上皮发生异型增生,最终发展成胃癌。幽门螺旋杆菌的致病因子在炎症到胃癌的发生中起着重要的作用,包括尿素酶、鞭毛、空泡毒素(VacA)、细胞毒素相关抗原(CagA)等。而这些致病因子诱发炎症的机制主要是启动了NF-κB通路,MAPK通路以及氧化应激,这三者之间也存在内在的联系。临床上治疗胃部炎症以及胃癌主要以抗生素、化疗药和外科手术为主,然而抗生素耐药、化疗药物的副作用以及术后复发使得治疗结果并不理想。因此,化学预防的提出给肿瘤的治疗提供了新的方向,特别是中草药的化学预防成为了研究的热点。本文主要总结了中草药对幽门螺旋杆菌导致胃癌的预防作用及其相关机制和治疗前景。
基金
Natural Science Foundation of China(Grant No.81120108025)
the Science and Technology Department of Guangzhou City(Grant No.201509010004)
