新诊断2型糖尿病伴高尿酸血症与血压及血脂相关性分析

Correlation of hyperuricemia with hypertension and dyslipidemia in patients with new-onset type 2 diabeetes mellitns

目的分析新诊断2型糖尿病（T2DM）合并高尿酸血症（HUA）者与血压及脂代谢紊乱的相关性。方法选取新诊断的T2DM患者170例，根据血尿酸（SUA）水平分为SUA正常组（NUA组）和HUA组，比较两组血脂、肾功能等临床指标的差异。结果新诊断T2DM患者中合并HUA的患病率为20．0％。HUA组舒张压（DBP）、腰围（WC）、体质量指数（BMI）、血肌酐（Scr）、尿微量白蛋白（UAER）、甘油三酯（TG）均高于NUA组（P〈0．05），而高密度脂蛋白胆固醇（HDL-C）低于NUA组（P〈0．05）。相关性分析显示，DBP、BMI、WC、TG、HDL-C、Scr及UAER是HUA的影响因素（P〈0．05）。结论新诊断T2DM患者高尿酸血症与高血压、肥胖、血脂异常及肾脏病变相关。

Objective To investigate the correlation ofhyperuricemia with hypertension and dyslipidemia in patients with new-onset type 2 diabetes mellitus （T2DM）. Methods A total of 170 newly diagnosed T2DM patients were enrolled and divided into a normal serum uric acid（NUA） group and a hyperuricemia（HUA） group according to serum uric acid levels. The clinical indexes such as lipids and renal function were compared between these two groups. Results The prevalence of HUA in newly diagnosed T2DM patients was 20.0%. Diastolic blood pressure（DBP）, waist circumference（WC）, body mass index（BMI）, serum creatinies（SCr）, 24 hour urinary albumin excretion rate（UAER）, triglycerides（TG）, and very low-density lipoprotein cholesterol（VLDL-C） were all higher and high density lipoprotein cholesterol（HDL-C） was lower in the HUA group than in the NUA group （P〈0.05）.According to multiple linear regression, DBP, BMI, WC, TG, HDL-C, and Scr were influence factors of HUA （P〈0.05）. Conclusions Hyperuricemia correlates with hypertension, obesity, and dyslipidemia in patients with new-onset T2DM.