颗粒蛋白前体与神经系统疾病

Progranulin in neurological diseases

颗粒蛋白前体(progranulin,PGRN)是一种分泌性糖蛋白,具有促进细胞增殖、抗炎、营养等多种生理功能,广泛参与炎症反应、损伤修复、生长发育及代谢调控等多项重要的病理及生理活动。近年来的研究表明,PGRN在神经系统疾病的发生与发展过程中具有重要的作用。综述了PGRN在脑组织中的表达、相关的信号通路及生物学功能,以及PGRN在各类神经系统疾病中的研究进展。

Progranulin （PGRN） is a secreted glycoprotein which has multiple physiological functions, including promoting cell proliferation, anti-inflammation, and trophic effect. It is involved in many important pathological and physiological events such as inflammation response, wound repair, growth and development, and metabolism. More recently, PGRN was recognized to play crucial roles in the occurrence and development of the neurological diseases. In this article, we reviewed the expression of PGRN in brain, related signaling pathways, biological functions, and the research progress of PGRN in different neurological diseases.