MR定量磁敏感图评估大脑灰质核团的引流静脉磁敏感值与铁沉积的相关性研究

The correlation between iron deposition of deep gray nuclei and cerebral venous susceptibility of drainage veins in healthy people using susceptibility mapping

目的采用MR定量磁敏感图测量不同年龄正常志愿者大脑灰质核团引流静脉的磁敏感值,观察其随年龄的变化趋势,以及与大脑灰质核团铁沉积的相关性。材料与方法使用Siemens 3.0 T MR,对57名正常志愿者进行磁敏感加权成像(SWI)扫描,获得相位图及幅度图,采用磁敏感图像成像与相位伪影消障工具(SMART)软件对相位图和幅度图进行处理得到定量磁敏感图(QSM),利用核磁共振信号处理(SPIN)软件在QSM上画出双侧大脑灰质核团引流静脉(丘脑纹状体静脉、透明隔静脉、大脑内静脉、基底静脉)及双侧大脑灰质核团(尾状核、苍白球、壳核、背侧丘脑、黑质、红核)的感兴趣区,然后分别测出不同静脉及灰质核团的磁敏感值。结果 57名正常志愿者左右两侧大脑灰质核团引流静脉磁敏感值无统计学差异(P值均>0.05)。57名正常志愿者两侧尾状核、黑质、红核的磁敏感值差异具有统计学意义,右侧高于左侧(t值分别为3.34、5.12、3.91,P值均<0.05)。右侧丘脑纹状体静脉的磁敏感值与年龄呈正相关(r=0.33,P<0.05)。左侧尾状核与左侧大脑内静脉、左侧壳核与左侧大脑内静脉、左侧红核与左侧大脑内静脉的磁敏感值呈正相关(r值分别为0.29、0.31、0.28,P值均<0.05)。结论右侧丘脑纹状体静脉磁敏感值随年龄增长有增加的趋势,大脑灰质核团引流静脉磁敏感值无侧别差异。部分大脑灰质核团铁沉积与其引流静脉磁敏感值呈正相关。

Objective： To evaluate age-related changes of cerebral venous susceptibility and the relationship between iron deposition of deep gray nuclei and the susceptibility of cerebral drainage veins in healthy people using MR quantitative susceptibility mapping（QSM）. Materials and Methods： Fifty-seven right-handed healthy individuals underwent SWI scanning to get phase images and magnitude images. QSM were reconstructed from the phase images and magnitude images using SMART software. The regions of interest include the bilateral cerebral veins（thalamostriate veins, septal veins, internal cerebral veins, basal veins） and the bilateral gray nuclei（caudate nucleus, globus pallidus, putamen, dorsal thalamus, substantia nigra, red nucleus） were drawn manually, and the susceptibility of cerebral gray nuclei and cerebral draining veins was measured using SPIN software. Results： There was no significant difference in susceptibility between the right and the left draining veins of cerebral gray nuclei in 57 healthy individuals（P〉0.05）. The susceptibility of right caudate nucleus, substantia nigra, red nucleus was higher than that of left sides（t value was 3.34, 5.12, 3.91, P〈0.05）. There was positive correlation between age andthe susceptibility of right thalamostriate vein（r=0.33, P〈0.05）. There were positive correlation of susceptibility between left caudate nucleus and left internal cerebral vein, left putamen and left internal cerebral vein, red nucleus and left internal cerebral vein（r value was 0.29, 0.31, 0.28, P〈0.05）. Conclusions： The susceptibility of right thalamostriate vein increased with aging.There was no side-difference in susceptibility between bilateral cerebral veins. The susceptibility of some draining veins has positive correlation with iron deposition of some gray nuclei.