莛子藨地上部分1个新的环烯醚萜

One new iridoid from aerial parts of Triosteum pinnatifidum

目的研究莛子藨Triosteum pinnatifidum地上部分的化学成分。方法采用溶剂萃取、薄层色谱以及硅胶、Sephadex LH-20、反相ODS等柱色谱方法进行化合物的分离和纯化,并综合运用1H-NMR、13C-NMR、COSY、HMBC、HSQC、NOESY、MS等波谱手段以及与对照品比对等方法鉴定化合物的结构。结果从莛子藨地上部分乙醇提取物正丁醇萃取部分中分离得到5个环烯醚萜化合物,分别鉴定为triohima C 10-O-β-D-glucopyranoside(1)、獐芽菜苷(2)、马钱子苷酸(3)、马钱子苷(4)、grandifloroside(5)。结论化合物1为新化合物,命名为莛子藨苷。

Objective To study the chemical constituents in the aerial parts of Triosteum pinnatifidum. Methods The compounds were separated and purified by solvent extraction, thin-layer chromatography and silica gel, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by extensive spectroscopic methods including 1D and 2D NMR experiments（1HNMR, 13C-NMR, COSY, HSQC, HMBC, and NOESY） along with HR-ESI-MS analyses and comparison with reference substances. Results Five iridoids were isolated from the butanol extraction fraction of ethanol extract from the aerial parts of T. pinnatifidum, and identified as triohima C 10-O-β-D-glucopyranoside（1）, sweroside（2）, loganic acid（3）, loganin（4）, and grandifloroside（5）. Conclusion Compound 1 is a new compound named triopinoside.