胃肠安丸合并蒿甲醚注射液治疗刚果(布)胃肠型疟疾临床观察

Treatment of malaria(gastrointestinal type) by Wei Chang An Pills combined with Artemether Injection in the Republic of Congo

目的观察胃肠安丸合并蒿甲醚注射液治疗刚果(布)胃肠型疟疾的临床疗效。方法选取刚果(布)中刚友好医院2013年7月—2014年12月诊断为胃肠型疟疾的253例患者,随机分为治疗组和对照组。治疗组130例患者给予蒿甲醚注射液(im)同时口服胃肠安丸,对照组123例患者给予蒿甲醚注射液(im)同时口服维生素B6片,7 d为1个疗程;观察两组患者恶心、呕吐、腹痛、腹泻症状改善情况,比较治疗前后便常规中白细胞、红细胞数量的变化及厚血片法检测外周血中疟原虫数量。结果治疗组第5天时130例患者症状全部消失,而对照组第7天时只有87例患者症状全部消失,两组差异显著(P<0.05);与对照组比较,治疗组能显著减少便常规中红细胞、白细胞的数量(P<0.05);治疗组与对照组相比能显著杀灭疟原虫(P<0.05)。结论胃肠安丸合并蒿甲醚注射液治疗刚果布胃肠型疟疾能显著改善胃肠道症状,缩短病程,还能起到辅助抗疟的作用。

Objective To investigate the clinical efficacy of Wei Chang An Pills combined with Artemether Injection in the treatment of malaria（gastrointestinal type）. Methods Patients（253 cases） with malaria（gastrointestinal type） in Hospital de L＇amitie Sino-Congolaise in The Republic of Congo from July 2013 to December 2014 were randomly divided into control and treatment groups. Patients（130 cases） in the treatment group were im administered with Artemether Injection and po administered with Wei Chang An Pills. Patients（123 cases） in the control group were im administered with Artemether Injection and po administered with Vitamin B6 Tablets. Patients in both two groups were treated for 7 d. After the treatment, the efficacy was evaluated, and the improvement of nausea, vomiting, abdominal pain, and diarrhea was observed, white blood cells and red blood cells in feces were simultaneously detected, numbers of plasmodium in peripheral blood were counted. Results After the treatment for 5 d, the clinical symptoms of all the patients（130 cases） in the treatment group disappeared. After the treatment for 7 d, clinical symptoms of patients（87 cases） in the control group disappeared, and there were differences between two groups（P〈 0.05）. Compared to the control group, white blood cells and red blood cells in feces of patients in the treatment group decreased significantly（P〈0.05）. The number of plasmodium in peripheral blood of patients in the treatment group was significantly decreased. Conclusion Wei Chang An Pills combined with Artemether Injection have the good effect in the treatment of malaria（gastrointestinal type）, and can improve the clinical symptoms of patients and shorten the course, and also have anti-malarial function.