复杂性区域疼痛综合征的研究进展

Advances in Complex Regional Pain Syndrome

复杂性区域疼痛综合征(CRPS)是对一种复杂症状和体征的描述,它包括疼痛和痛觉超敏、运动功能障碍、肿胀、血管舒缩不稳定、皮肤颜色改变、体温和汗腺分泌异常等。到目前仍没有诊断标准和循证医学完整的定义。CRPS被分为Ⅰ型和Ⅱ型。Ⅰ型包括反射性交感神经营养不良症及类似病症,没有神经损伤;而Ⅱ型发生在周围神经损伤之后。本文将对CRPS在流行病学、病理生理学、诊断和治疗等方面的研究进展作一概述,以帮助临床解决与CRPS相关的诊治难题。

Complex regional pain syndrome（CRPS）is a descriptive term for a complex of symptoms and signs,including pain,hyperesthesia,motor dysfunction,swelling,vasomotor instability,skin color change,temperature abnormality,sweat gland abnormality,etc.At present,there are still no standards for the diagnosis and complete definitions of evidence-based medicine.CRPS is classified into two different types.CRPS typeⅠencompasses reflex sympathetic dystrophy and similar disorders without nerve injury.While CRPS typeⅡ occurs after peripheral nerve injury.This article reviews the advances in epidemiology,pathophysiology,diagnosis and treatment of CRPS.We believe that this review may help doctors to resolve the diagnostic and treatment dilemmas associated with CRPS.