FGF21在骨关节炎患者关节液中的表达及意义被引量：1

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摘要目的通过检测不同阶段的膝骨关节炎（KOA）患者关节滑液中成纤维细胞生长因子21（FGF21）的浓度,探讨FGF21与骨关节炎严重程度的相关性和骨性关节炎的发病机制.方法选取KOA患者103例,以Kellgren-Lawrence （K-L）分级方法对KOA患者膝关节放射学严重程度进行评估分组,分为OA1、OA2、OA3组,采用酶联免疫吸附法（ELISA）测定各组中FGF21的浓度,同时检测白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-αt）的浓度,验证实验结果的可行性.结果 OA1组的FGF21、TNF-αt、IL-1β含量低于OA2、OA3组,差异有统计学意义（P＜0.05）,OA2组的FGF21、TNF-α、IL-1β含量低于OA3组,差异有统计学意义（P＜0.05）.关节液中FGF21、IL-1β、TNF-α的浓度与K-L分级的严重程度呈正相关（r=0.899,0.94,0.925,P＜0.05,P＜0.01）.结论关节液中的FGF21、IL-1β、TNF-α的浓度和K-L分级的严重程度相关.

作者潘建康黎志宏

机构地区开封市中心医院湘雅二医院骨科

出处《中国医师杂志》 CAS 2016年第4期607-608,共2页 Journal of Chinese Physician

关键词成纤维细胞生长因子/代谢骨关节炎膝/代谢滑液/代谢

分类号 R684.3 [医药卫生—骨科学]

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