眼底动脉硬化与不同类型脑白质疏松的相关性

Correlation between fundus arteriosclerosis and different types of leukoaraiosis

目的:探讨眼底动脉硬化与不同类型脑白质疏松症(LA)的相关性。方法:2013-2014年本院体检中心的LA患者101例,按头颅磁共振成像(MRI)的脑白质疏松部位分为3组:脑室周围型(第一组)40例、皮质下型(第二组)31例、混合型(第三组)30例。对101例白质疏松患者及正常对照30例进行眼底数码照相分析。观察分析各组患者眼底动脉硬化差异。结果:白质疏松患者与正常对照组比较,眼底动脉硬化程度差异有统计学意义(P<0.05)。不同类型白质疏松患者的眼底动脉硬化程度有差异(P<0.05)。第二组与第三组患者的动脉硬化程度较第一组明显(P<0.05),而第二组与第三组的动脉硬化程度无差异(P>0.05)。结论:眼底动脉硬化与LA有相关性,眼底动脉硬化程度与皮质下性及混合型白质疏松相关性大。

Objective：To investigate the correlation between fundus arteriosclerosis and different types of leukoaraiosis（LA）.Methods：A total of 101 LA patients examined in the Health Examination Center of our hospital between 2013 and 2014 were included in the study.According to the LA sites by magnetic resonance imaging（MRI）,all patients were divided into three groups：periventricular type（Group 1,n= 40）,subcortical type（Group 2,n=31）,mixed type（Group 3,n = 30）.A total of 101 LA patients and 30 normal controls were analyzed by fundus digital photography.The differences of fundus arteriosclerosis among the three groups were determined.Results：There was statistically significant difference in the degree of fundus arteriosclerosis between the LA patients and the normal controls（P〈0.05）.There was difference in the degree of fundus arteriosclerosis among patients with different types of LA（P〈0.05）.The degree of fundus arteriosclerosis in Group 2 and Group 3 was more significant than that in Group 1（P〈0.05）.However,there was no difference in the degree of fundus arteriosclerosis between Group 2 and Group 3（P〉0.05）.Conclusion;There is correlation between fundus arteriosclerosis and LA.The degree of fundus arteriosclerosis is significantly correlated with subcortical and mixed LA.