原发性高血压患者报告结局、生命质量与基因多态性的关系初探

Preliminary study on relationships between patients-reported outcomes,quality of and life gene polymorphism in essential hypertension

目的初步探讨原发性高血压相关基因多态性与患者报告结局、生命质量的关系。方法通过文献寻找影响原发性高血压发生发展及心理方面的基因,通过专家咨询和核心小组讨论等方法筛选可能与患者报告结局、生命质量相关的基因。结果高血压易感基因有血管紧张素原、血管紧张素转化酶、醛固酮合成酶基因;与情感情绪相关的基因有多巴胺D2受体基因、5-羟色胺转运体基因。结论这些基因可能影响原发性高血压患者报告结局、生命质量。

Objective To explore preliminarily the relationships between gene polymorphism and patients reportedoutcomes（PRO） and quality of life（QOL） in essential hypertension（EH）. Methods The genes related to EH progression,psychology,PRO and QOL in EH patients were screened using literatures review,experts＇ consultation and focus group discussion. Results The susceptible genes of EH included angiotensinogen,angiontensin converting enzyme,and aldosterone synthase genes,while the dopamine D2 receptor and 5-hydroxytryptamine transporter genes were responsible for emotional behavior. Conclusion These genes might influence on PRO and QOL in patients with EH.