FGF-21、血脂代谢、hsCRP及脐血流在预测子痫前期中的意义

The significance of FGF-21,blood lipid metabolism,hsCRP and umbilical blood flow in the prediction of preeclampsia

目的了解血成纤维细胞生长因子-21(FGF-21)、血脂代谢、超敏C反应蛋白(hs CRP)及脐血流在预测子痫前期中的意义。方法选择单胎子痫前期孕妇89例为研究组,同期正常妊娠的孕妇83例为对照组,在生化分析仪上测定血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDLC)、低密度脂蛋白(LDLC)水平;ELISA法测定研究组和对照组中孕妇血FGF-21水平;免疫透射比浊法测定孕妇血hs CRP的质量浓度;三维彩色多普勒诊断仪检测脐动脉血流S/D值。结果与对照组比较,研究组的TC、LDLC、FGF-21、hs CRP水平及脐动脉血流S/D值明显升高,而HDLC水平则降低,差异均有统计学意义(P<0.01)。子痫前期FGF-21水平与TC、TG、LDLC呈正相关(P<0.05),与HDLC负相关,而与hs CRP及脐动脉血流S/D值无相关性(P>0.05)。结论血FGF-21水平的升高可能是子痫前期的一个独立危险因素,对预测子痫前期的发生有一定的意义。

Objective To investigate the significance of FGF-21,blood lipid metabolism,hs CRP and umbilical blood flow in the prediction of preeclampsia. Methods 89 cases of pregnant women with single fetus in preeclampsia were selected as Study Group,and 83 cases of healthy pregnant women at the same period were selected as control group; Total cholesterol（TC）,triglyceride（TG）,high density lipoprotein（HDLC） and low density lipoprotein（LDLC） were measured by biochemical analyzer; FGF-21 was measured by enzyme-linked immunoassay（ELISA）; hs CRP was measured by Immune transmission turbidity; and the umbilical artery blood S/D was determined by 3D-color Doppler echocardiography. Results Compared with Control Group,Study Group had a significantly higher TC,HDLC,LDLC,umbilical artery blood S/D（P〈0.05）,but had a decreased level of HDLC,and the difference was statistically significant（P〈0.01）. Serum level of FGF-21 in preeclampsia was positively correlated to TC,TG and LDLC（P〈0.05）,but have no correlation to umbilical artery blood S/D（P〈0.05）. Conclusion Increased serum level of FGF-21 may be an independent factor for preeclampsia,which may be of significance for early detection of preeclampsia.