药食同源植物醛糖还原酶抑制剂的筛选

Screening of ARI from Medicinal and Edible Plant

选取50余种药食同源植物,根据糖尿病并发症的病发机理,筛选含有有效醛糖还原酶抑制剂(ARI)的天然成分,利用测定的IC_(50)值作为参考,比对各已知有抑制活性的样本植物的醛糖还原酶(AR)抑制效率.结果表明:柠檬、苦瓜、李子和石榴的ARI活性较强,其IC_(50)值分别为0.74,0.64,0.25,0.027mg/mL.

According to the mechanism of disease of diabetic complication,we selected 50 kinds of medicinal and edible plants,and screened containing effective natural ingredients of aldose reductase inhibitors（ARI）.By measuring the IC50 value as a reference,we compared the samples known to inhibit the activity of ARI efficiency in plants.The results show that the ARI activity of lemon,balsam pear,plum and pomegranate are strong.Their IC50 values are 0.74,0.64,0.25,0.027mg/mL.