复方苦参注射液联合化疗对晚期非小细胞肺癌的作用研究

Effect of Compound Matrine Injection Combined with Chemotherapy in Treatment of Advanced Non-Small Cell Lung Cancer

目的探讨复方苦参注射液联合化疗对晚期非小细胞肺癌的作用。方法选取我院2011年12月至2013年12月收治的80例晚期非小细胞肺癌患者．随机分为试验组和对照组各40例，对照组采用化疗方法治疗，试验组在对照组的基础上进行复方苦参注射液治疗，观察比较两组的治疗效果。结果试验组的总有效率为87．5％，显著高于对照组的62．5％，差异具有统计学意义（x^2=7．833，P〈0．05）。试验组的不良反应发生率为20．0％，显著低于对照组的50．0％，差异具有统计学意义（x^2=7．912，P〈0．05）。治疗后试验组的生活质量评分显著高于对照组，差异具有统计学意义（P〈0．05）。结论采用复方苦参注射液联合化疗治疗晚期非小细胞肺癌可以有效改善患者的症状，降低不良反应的发生率，提高患者的生活质量，具有重要的临床意义。

Objective To explore the effect of compound matrine injection combined with chemotherapy in treatment of patients with advanced non-small cell lung cancer. Methods Eighty cases of patients with advanced non-small cell lung cancer admitted to our hospital from December 2011 to December 2013 were selected and randomly divided into two groups, with 40 cases in each group. The control group was treated with chemotherapy, while the experimental group was treated with compound matrine injection combined with chemotherapy. The curative effects of two groups were compared. Results The total effective rate of treatment of experimental group was 87.5%, significantly higher than 62,5% of control group （x^2 = 7.833, P〈0.05）. The incidence of adverse reactions of experimental group was 20.0%, significantly lower than 50.0% of control group （x^2 = 7.912, P〈0.05）. The score of quality of life after treatment of experimental group was significantly higher than that of control group （P〈0.05）. Conclusions Compound matrine injection combined with chemotherapy in treatment of advanced non-small cell lung cancer can effectively improve patients＇ symptoms, reduce the incidence of adverse reactions, and improve patients＇ quality of life.