摘要
目的研究窄谱中波紫外线(NB-UVB)治疗寻常性银屑病的临床疗效以及对患者Th1/Th2的影响,探讨NB-UVB治疗寻常性银屑病的机制。方法 55例寻常性银屑病患者采用NB-UVB光疗。采用流式细胞技术分别于光疗前、光疗20次后检测患者外周血中CD4^+CCR5^+和CD4^+CD30^+细胞的表达;同时检测50例健康人作为对照组。结果治疗前银屑病组CCR5^+细胞的百分比均高于对照组(P<0.05);CD30^+细胞的百分比较对照组明显降低(P<0.05)。患者光疗后得到明显改善(P<0.01)。结论 NB-UVB可有效调节银屑病患者Th1/Th2表达失衡,这可能是NB-UVB治疗银屑病免疫学机制之一。
Objective In order to study the rebalance of Th1/Th2 in patients with psoriasis vulgaris who received the narrow-band ultraviolet B（ NB-UVB） therapy, and to explore the mechanism of ultraviolet therapy in psoriasis with NB-UVB.Methods 55 patients were treated with NB-UVB radiation only. CD4~＋CCR5~＋and CD4~＋CD30~＋Treg were measured by flow cytometric analysis before and after 20 times in patients who were treated with NB- UVB radiation. 50 healthy people were enrolled as controls. Results The proportion of CCR5~＋cells were significantly increased in psoriasis（P〈0.05）,compared with controls. The level of CD30~＋in patients was siganificantly decreased（P〈0.05）. After treated with NB-UVB,Th1/Th2 expression was changed（P〈0.01）. Conclusion Radiation of NB-UVB works well on Th1/Th2 in patients, and it may take effect through the cell immunity.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2016年第2期78-80,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金
广东省中医药局(20131075)
广东省卫计委(A2014883)
