低度恶性腹膜囊性间皮瘤19例临床病理学观察

Clinicopathological analysis of low-grade malignant cysitic mesothelioma of the peritoneum

目的 观察低度恶性腹膜囊性间皮瘤的临床与病理特点。方法 采用HE染色、组织化学、免疫组化技术对 19例低度恶性腹膜囊性间皮瘤进行观察 ,其中 9例标本做了电镜检查。结果 本组以中年女性多见 ,主要症状为腹部疼痛或不适 ,6例为局限单发性囊性肿块型 ,7例为多发性囊性结节型 ,6例为弥漫性囊性结节型 ,其中 8例肿瘤复发。 19例肿瘤细胞CI均 (+) ,而HCI均 (- )。肿瘤细胞胞浆内keratin、vimentin及EMA等均 (+)。结论 低度恶性腹膜囊性间皮瘤是一种具有临床和病理特征的原发性肿瘤 ,手术治疗预后好。

Objective To observe the clinicopathological changes of low grade malignant cysitic mesothelioma of the peritoneum(LGMCMP). Methods Nineteen cases of LGMCMP were studied with HE staining, histochemistry and immunohistochemistry, in which 9 cases were studied with electron microscope. Results The majority of the patients were middle aged women. The main symptoms were abdominal pain or discomfort . On pathological examination, 6 of them were sole cystic mass, 7 multiple cystic modules, and another 6 diffuse cystic nodules, 8 cases had recurrence. Hyaluronidase digested colloidal iron was negative, while colloidal iron were positive in all the cases. Immunohistochemical analysis showed that tumor cells expressed keratin,vimentin and EMA. Conclusions LGMCMP is a low grade malignant tumor with clinicopathologic characteristics and can be cured by local excision.