地高辛联合美托洛尔治疗老年顽固性房颤的临床效果观察

目的探讨地高辛与美托洛尔联合应用控制老年顽固性房颤患者转复心室率并长期维持的临床疗效观察。方法选取老年顽固性房颤患者经治疗后的临床效果进行分析,将78例符合入组条件的持续性房颤患者,随机分为2组,对照组39例,维持单一地高辛治疗;试验组39例,使用地高辛联合美托洛尔治疗,观察2组治疗前后静息心室率、活动后的最高心率、最低心率及不良反应的发生情况。结果试验组组患者房颤伴快速心室率病情治疗效果为89.7%,显著优于对照组的治疗效果72.0%(P<0.05);2组患者均未出现严重的药物不良反应;试验组治疗后3个月随访的最高心率(115.0±13.9)次/分,低于对照组,差异有统计学意义(P<0.05)。最低心率(90.0±18.1)次/min及静息心率(97.0±9.6)次/min与对照组相比,差异无统计学意义。结论地高辛与美托洛尔联合应用可作为控制持续性房颤并心室率的首选药物之一,对老年患者效果较好,值得在临床推广使用,但应注意谨慎用药,密切观察病情,以防并发症的发生。

Objective To explore corresponding land use digoxin and metoprolol combined control the clinical effect of the treatment of disease in elderly patients with refractory atrial fibrillation. Methods In elderly patients with refractory atrial fibrillation after treatment of clinical data were retrospectively analyzed, select 78 cases of patients with persistent af, randomly divided into two groups, one group is controlled to maintain a single digoxin treatment way, another group with metoprolol therapy group, observation resting ventricular rate in two groups before and after treatment, after the heart rate, and the occurrence of adverse reactions. Results Test way in patients with atrial fibrillation with rapid ventricular rate disease treatment effect is better than the control group; Two groups of patients with no serious adverse drug reactions occurred. Conclusion Digoxin and metoprolol combined application can be used as one of the preferred drug for ventricular rate control and persistent af, for elderly patients with effect is good, is worth popularizing in clinical use, but should pay attention to drug use, carefully observing closely, to prevent the occurrence of complications.