分泌血清素的恶性胰腺内分泌肿瘤1例及文献复习

Serotonin-producing tumor of the pancreas: report of a case and review of literature

目的 探讨分泌血清素的恶性胰腺内分泌肿瘤的临床病理特点、诊断和预后。方法 对 1例分泌血清素的恶性胰腺内分泌肿瘤进行光镜、免疫组化观察并结合文献进行分析。结果 肿瘤细胞大小一致 ,圆形或多边形 ,呈实性成片状、巢索状排列 ,未见核分裂 ,胞质嗜酸性 ,向周围浸润 ,侵犯神经。淋巴结内见癌转移。NSE、CgA、Syn和serotonin阳性。结论 分泌血清素的恶性胰腺内分泌肿瘤来源于外分泌导管或腺泡上皮的Kultschitsky细胞 ,具有典型的神经内分泌肿瘤的组织学特征 ,常伴有类癌综合征 ,属低度恶性 ,病理诊断依赖于组织学。

Objective To investigate the clinical pathological characteristics,diagnosis and prognosis of serotonin producing tumor of the pancreas Methods A case of serotonin producing tumor of the pancreas was analyzed with light and immunohistochemical stains and literature review Results The tumor cells were round with eosinophilic cytoplasm,the former showing a nest, isomorphic or solid growth pattern, infiltrating into the organ with nervous invasion and lymph node metastases Mitoses can not be seen The tumor cells were positive for NSE, CgA, Syn and serotonin Conclusions Serotonin producing tumor of the pancreas is derived from the argentaffin Kultschitsky's cells of the pancreatic exocrine ducts The diagnosis of the tumor is based on the typical endocrine histological features together with carcinoid syndrome and immunohistochemical findings The biological behavior is low grade malignant