较低剂量氟哌噻吨美利曲辛治疗功能性消化不良疗效观察

Clinical observation of lower dose of flupenthixol and melitracen in the treatment of func-tional dyspepsia

目的：探讨较低剂量氟哌噻吨美利曲辛治疗功能性消化不良的临床效果。方法将80例功能性消化不良患者随机分为研究组和对照组，每组40例。对照组给予临床常规治疗，研究组在常规治疗基础上加用较低剂量氟哌噻吨美利曲辛片，记录两组治疗前后心理抑郁状态变化情况，经统计学分析并获得结论。结果研究组临床总有效率（87.50%）显著高于对照组（72.50%），两组比较差异有统计学意义（P〈0.05）；经不同方法治疗后两组 HADM 评分均较治疗前有所改善，但研究组改善效果优于对照组（P〈0.05）。结论对功能性消化不良患者给予常规治疗基础上加用低剂量氟哌噻吨美利曲辛片可显著提高其临床疗效，有利于缓解患者不良情绪，保障其生活质量。

Objective To investigate the clinical effect of lower dose of flupentixol and melitracen on functional dyspepsia. Methods Eighty patients with functional dyspepsia were randomly divided into two groups,with 40 cases in each group. The control group received routine clinical treatment,study group were treated with lower dose of flupentixol and melitracen on the basis of conventional therapy. The changes in mental depression before and after treatment were recorded. Results The total efficiency of study group（87. 50% ）was significantly higher than that of control group（72. 50% ）,P〈 0. 05;After treatment,the HADM score were all improved than before treatment,but the study group improvement was better than that of control group（P〈 0. 05）. Conclusions Conventional therapy plus low-dose flu-pentixol and melitracen in the treatment of functional dyspepsia,can significantly improve the clinical ef-ficacy,and alleviate the negative emotions of patients,ensure their quality of life.