摘要
目的:探讨骨质疏松患者采用唑来膦酸注射液+钙制剂+维生素 D(VD)对症状缓解的效果。方法选取灵宝市第一人民医院2013年2月至2015年2月收治的骨质疏松患者60例,随机分为钙制剂+ VD 治疗组(对照组)与联用唑来膦酸注射治疗组(观察组),每组30例。比较两组患者的临床效果。结果两组患者治疗前左股骨大粗隆骨密度、第1~4腰椎骨密度、降钙素、甲状旁腺激素、骨钙素、肌酐、血清磷、血清钙差异未见统计学意义(P〉0.05),治疗后观察组左股骨大粗隆骨密度、腰椎 L1-4骨密度明显升高、甲状旁腺激素有所降低,与治疗前及对照组比较差异有统计学意义(P〈0.05),其他指标两组均无明显变化。两组均无严重不良反应。结论骨质疏松在钙制剂+维生素 D 常规治疗基础上,加用唑来膦酸,可显著改善患者机体情况,防范不良事件发生,保障生存质量。
Objective To investigate the clinical effect of Zoledronic acid injection + calcium preparations + VD on symptoms mitigation patients with osteoporosis. Methods From February 2013 to February 2015,sixty cases of osteoporosis in the First People’s Hospital of Lingbao were selected and randomly divided into calcium preparations + VD treatment group( control group)and in combination with zoledronic acid injection treatment group(study group)with 30 cases in each group. The clinical effects were compared. Results There was no significant difference in the osteoporosis left greater tro-chanter BMD L1 - 4 lumbar spine bone mineral density,calcitonin,parathyroid hormone,osteocalcin, creatinine,serum phosphorus,serum calcium pre-treatment between the two groups(P〉 0. 05). After treatment in the observation group,left femoral trochanter BMD L1 - 4 lumbar spine BMD increased sig-nificantly,parathyroid hormone decreased,there were significant differences compared with before treat-ment and control group(P〈 0. 05). There were no significant changes in other indicators. There were no serious adverse reactions. Conclusions Osteoporosis,calcium and vitamin D preparations conventional therapy,taking zoledronic acid plus can significantly improve patients’body and prevent adverse events. This path has important meaning in the protection of the quality of life.
出处
《中国实用医刊》
2016年第7期29-30,共2页
Chinese Journal of Practical Medicine
关键词
唑来酸注射液
钙制剂
维生素D
骨质疏松
症状缓解
对照
Zoledronic acid injection
Calcium preparations
Vitamin D
Osteoporosis
Symptoms relive
Control