高浓度七氟烷用于小儿麻醉诱导的临床探讨

Clinical exploration of high concentration of sevoflurane in pediatric anesthesia induction

目的：探讨高浓度七氟烷在小儿麻醉诱导中的应用效果。方法回顾性分析2014年1月至2015年1月在商丘市第三人民医院接受手术治疗的患儿60例，随机分为两组，每组30例，其中对照组给予面罩吸纯氧加七氟烷3%，观察组给予面罩吸纯氧加七氟烷8%。两组麻醉维持浓度均控制在2%～4%。比较两组睫毛反射消失时间、平均动脉压及心率变化，并记录两组不良反应情况。结果两组麻醉诱导均成功，成功率为100%；观察组睫毛反射消失时间、平均动脉压及心率变化均显著优于对照组，差异有统计学意义（P〈0.05）。观察组不良反应发生率为6.7%，对照组为10%，差异未见统计学意义（P〉0.05）。结论高浓度七氟烷用于小儿麻醉诱导中麻醉效果显著，诱导速度较快，且无严重不良反应，安全性高，值得临床进一步推广应用。

Objective To investigate the effect of high concentrations of sevoflurane application of induction of anesthesia in children. Methods Retrospectively analyzed 60 children undergoing sur-gery from January 2014 to January 2015 and randomly divided them into two groups with 30 cases in each group. The control group received sevoflurane mask inhaling pure oxygen plus 3% ,and the observation group were inhaling pure oxygen mask sevoflurane plus 8% . Anesthesia was maintained control two con-centrations between 2% and 4% . Compared the eyelash reflex time,mean arterial pressure and heart rate of the two groups,and record two adverse reactions. Results Both groups were successful induction of anesthesia,the success rate was 100% ;the observation group eyelash reflex time,mean arterial pres-sure and heart rate were significantly better than the control group,there was statistically significant difference between the two groups（P〈 0. 05）. The incidence of adverse reactions in observation group was 6. 7% and that in the control group was 10% ,incidence of adverse reactions had no significant difference between the two groups（P〉 0. 05）. Conclusions High concentrations of sevoflurane in ped-iatric anesthesia,the anesthetic effect is remarkable,induce faster,and no serious adverse reactions, safe,so it is worthy of further clinical applications.