法舒地尔治疗68例脑血管痉挛患者的疗效与安全性探讨

Analysis on the efficacy and safety of fasudil against cerebral vasospasm based on 68 cases of cerebral vasospasm patients

目的：探讨对脑血管痉挛患者采用法舒地尔治疗的临床效果与安全性。方法选取漯河市第二人民医院2013年2月至2014年2月收治的脑血管痉挛患者68例作为研究对象，对其临床资料进行回顾性分析。按照治疗方式分为对照组和观察组。对照组34例采用尼莫地平治疗，观察组34例采用法舒地尔治疗，对比两组患者的临床效果及安全性。结果对照组临床疗效为73.5%，明显低于观察组的91.2%，差异具有统计学意义（P〈0.05）；观察组 ESS、GOS 以及 MRS 评分均优于对照组，差异具有统计学意义（P〈0.05）；对照组不良反应发生率为14.0%，观察组无不良反应发生，差异具有统计学意义（P〈0.05）。结论法舒地尔治疗脑血管痉挛患者临床疗效明显，且安全性好，可改善预后，有推广价值。

Objective To investigate the clinical efficacy and safety of fasudil against cerebral vasospasm. Methods By analyzing the records of 68 patients with cerebral vasospasm in the Second Peo-ple’s Hospital of Luohe from February 2013 to February 2014,all the patients were divided into two groups （the control group with nimodipine,while the observatory with fasudil）,and compared the clinical efficacy and safety of the two groups. Results The clinical efficacy of the control group was 73. 5%,while of ob-servatory group was 91. 2% ,which was significantly higher than the former one（P〈0. 05）;the ESS,GOS and MRS evaluation of observatory group also significantly outperforms than the control group（P〈0. 05）;moreover,in terms of adverse reactions,significant difference also been observed between the control group （14. 0% ）and the observatory group（0. 0% ）（P〈0. 05）. Conclusions Fasudil shows better clinical ef-ficacy,a safer performance in adverse reactions as well as a more favorable prognosis. According to this ex-perimental result,the popularization of fasudil could provide better clinical application.